ADAM10 anticorps (AA 732-748)

N° du produit ABIN264988

Cet anticorps Lapin Polyclonal détecte spécifiquement ADAM10 dans WB. Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour ADAM10 anticorps (AA 732-748) (ABIN264988)

Antigène: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADAM10 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ADAM10 anticorps

Épitope: AA 732-748

Specificité: This antibody recognizes ADAM10.

Purification: Purified

Immunogène: Synthetic peptide corresponding to amino acids 732-748 off the Human ADAM10.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 0.25-1 μg/mL. Detects an 85 kDa band can be detected in Jurkat cell lysates which may representprecursor protein. A faint 60 kDa band is also detected in some cell lines, including Jurkat,which may be processed mature protein. Positive Control/Tissue Expression: Jurkat whole cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline solution containing 0.02 % Sodium Azide as a preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C.

Détails sur ADAM10

Antigène: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Autre désignation: CD156c / ADAM10

Sujet: Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively, (1,2,4). ADAM10 mRNA is expressed in a variety of human and bovine tissues (1,4).Synonyms: Disintegrin and metalloproteinase domain-containing protein 10, KUZ, Kuzbanian protein homolog, MADM, Mammalian disintegrin-metalloprotease

ID gène: 102

NCBI Accession: NP_001101

UniProt: O14672

Pathways: Signalisation Notch, EGFR Signaling Pathway